What Is VDR?

VDR is a gene that codes for a protein that acts as a receptor for vitamin D which regulates bone growth and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with a lower bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter https://www.gescheftmarketing.de/2021/09/01/microsoft-teams-vs-zoom-which-one-is-better/ regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of on- and off occupancy of the VDRE by the two components, and it is influenced by chromosomal location and binding preferences for certain hormones. Microarray studies of human cells reveal that more than 100 genes carry an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) could be an archive of data and documents relevant to business, legal transactions or other proceedings. Access to the data, downloading, or printing is restricted. It uses a central computer and an extranet which is a restricted access Internet connection, allowing users to access the internet at specific times.

Companies involved in investment banking and in mergers and acquisitions are among the most common users of a VDR. They must be able to communicate information in a clear manner with potential investors or buyers. Due diligence procedures can also require a large amount of data. Life science companies also use VDRs to store everything from clinical trial results to HIPAA documentation.